Butyrolactone 3

MedChem Express

Butyrolactone 3 [778649-18-6]

9

778649-18-6

Research Use Only

99.58

C9H12O4

184.191

Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 ( IC 50 =100 microM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP ( IC 50 =0.5 mM). Butyrolactone 3 can be used in studies of cancer, metabolic, autoimmune and neurological diseases [1] [2] [3] .

O=C([C@@H](C1=C)[C@@H](CCC)OC1=O)O

-20°C

12352200