Butyrolactone I [87414-49-1]

BioViotica

Butyrolactone I [87414-49-1]

10

87414-49-1

Research Use Only

>98%

Warning

C24H24O7

424.5

Cell permeable, potent and selective cyclin-dependent kinase CDK-1 (CDC2), -2 and -5 inhibitor [1-4, 9, 10]. Apoptosis inducer [6, 7, 9]. Antitumor agent [5, 9]. Inhibits cell cycle progression at the G1/S and G2/M transitions [8]. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone [2, 10]. Important probe for understanding the cellular roles of CDKs [4]. Inhibitor of alpha-glucosidases [12]. Maturation inhibitor of sheep oocytes [11]. - Chemical. CAS: 87414-49-1. Formula: C24H24O7. MW: 424.5. Isolated from Aspergillus terreus. Cell permeable, potent and selective cyclin-dependent kinase CDK-1 (CDC2), -2 and -5 inhibitor. Apoptosis inducer. Antitumor agent. Inhibits cell cycle progression at the G1/S and G2/M transitions. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Important probe for understanding the cellular roles of CDKs. Inhibitor of alpha-glucosidases. Maturation inhibitor of sheep oocytes.

COC(=O)[C@]1(CC2=CC=C(O)C(CC=C(C)C)=C2)OC(=O)C(O)=C1C1=CC=C(O)C=C1

-20°C,2°C to 8°C

12352200