c-Abl (phospho Tyr245) antibody

GeneTex

c-Abl (phospho Tyr245) antibody

9

This antibody is raised against mouse c-Abl (P00520-1) phosphorylated at Tyr226. Based on sequence homology, it is predicted to react with human c-Abl when phosphorylated at the corresponding residues - c-Abl (isoform a) Tyr226 or c-Abl (isoform b) Tyr245

WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

1.08 mg/ml

Unconjugated

Abl1

c-abl oncogene 1, non-receptor tyrosine kinase

Abelson murine leukemia oncogene; abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Abl; AI325092; c-A; c-Abl; c-abl oncogene 1, receptor tyrosine kinase; c-abl protein, type I; c-abl protein, type II; c-abl protein, type III; E430008G22Rik; p150; proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia oncogene 1

Rabbit

IgG

Tyrosine-protein kinase ABL1

Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203