Western blot analysis of extracts of various cell lines using CSF1R Polyclonal Antibody at dilution of 1:500.
Western blot analysis of extracts of various cell lines using CSF1R Polyclonal Antibody at dilution of 1:500.
c-Fms Polyclonal Antibody
E-AB-60816
Product group Antibodies
Overview
- SupplierElabscience
- Product Namec-Fms Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThe protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma.
- UNSPSC12352203