c-Met-IN-12 [2426675-70-7]

MedChem Express

c-Met-IN-12 [2426675-70-7]

10

2426675-70-7

Research Use Only

C34H29FN4O4

576.62

c-Met-IN-12 (compound 4r) is an orally active, potent and selective type II c-Met kinase inhibitor, with an IC50 of 10.6 nM. c-Met-IN-12 displays high inhibitory effects (inhibition rate > 80% in 1 microM) against AXL, Mer and TYRO3 kinases. c-Met-IN-12 can be used a scaffold for further kinase selectivity enhancement. c-Met-IN-12 shows antitumor efficacy[1].

CN(C1=CC=NC(NC2=CC(F)=C(C=C2)OC3=C4C=CC(OCC(C)(O)C)=CC4=NC=C3)=C1C5=O)C=C5C6=CC=CC=C6

12131703