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ProductsBack/c-Myc antibody
Sample (whole cell lysate) A: 293T 20ug B: 293T 10ug 10% SDS PAGE GTX103436 diluted at 1:1000 The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
Sample (whole cell lysate) A: 293T 20ug B: 293T 10ug 10% SDS PAGE GTX103436 diluted at 1:1000 The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
Sample (whole cell lysate) A: 293T 20ug B: 293T 10ug 10% SDS PAGE GTX103436 diluted at 1:1000 The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

c-Myc antibody

GTX103436
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Xenopus
TargetMYC
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Overview

  • Supplier
    GeneTex
  • Product Name
    c-Myc antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.29 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID4609
  • Target name
    MYC
  • Target description
    MYC proto-oncogene, bHLH transcription factor
  • Target synonyms
    MRTL, MYCC, bHLHe39, c-Myc, myc proto-oncogene protein, avian myelocytomatosis viral oncogene homolog, class E basic helix-loop-helix protein 39, myc-related translation/localization regulatory factor, proto-oncogene c-Myc, transcription factor p64, v-myc avian myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene homolog
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP01106
  • Protein Name
    Myc proto-oncogene protein
  • Scientific Description
    The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitts lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Xenopus
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Su WC, Hung CF, Wang YC, et al. Thiamet G as a Potential Treatment for Polycystic Kidney Disease. In Vivo. 2023,37(6):2524-2532. doi: 10.21873/invivo.13360
    Read this paper
  • Lin CY, Ching YY, Wu SF, et al. Coating-Free Culture Medium for Establishing and Maintaining Human Induced Pluripotent Stem Cells. Cell Transplant. 2023,32:9636897231198172. doi: 10.1177/09636897231198172
    Read this paper
  • Mushtaq I, Bhat GR, Rah B, et al. Telomere Attrition With Concomitant hTERT Overexpression Involved in the Progression of Gastric Cancer May Have Prognostic and Clinical Implications in High-Risk Population Group From North India. Front Oncol. 2022,12:919351. doi: 10.3389/fonc.2022.919351
    Read this paper
  • Hsu WJ, Chen CH, Chang YC, et al. PRMT1 Confers Resistance to Olaparib via Modulating MYC Signaling in Triple-Negative Breast Cancer. J Pers Med. 2021,11(10). doi: 10.3390/jpm11101009
    Read this paper
  • Huang CY, Weng YT, Li PC, et al. Calcitriol Suppresses Warburg Effect and Cell Growth in Human Colorectal Cancer Cells. Life (Basel). 2021,11(9). doi: 10.3390/life11090963
    Read this paper
  • Wu MJ, Chen CJ, Lin TY, et al. Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer. Theranostics. 2021,11(16):7779-7796. doi: 10.7150/thno.58729
    Read this paper
  • Qiu S, Chen X, Zhai Y, et al. Downregulation of Light-Harvesting Complex II Induces ROS-Mediated Defense Against Turnip Mosaic Virus Infection in Nicotiana benthamiana. Front Microbiol. 2021,12:690988. doi: 10.3389/fmicb.2021.690988
    Read this paper
  • Lee CC, Ho KH, Huang TW, et al. A regulatory loop among CD276, miR-29c-3p, and Myc exists in cancer cells against natural killer cell cytotoxicity. Life Sci. 2021,277:119438. doi: 10.1016/j.lfs.2021.119438
    Read this paper
  • Ge J, Yu W, Li J, et al. USP16 regulates castration-resistant prostate cancer cell proliferation by deubiquitinating and stablizing c-Myc. J Exp Clin Cancer Res. 2021,40(1):59. doi: 10.1186/s13046-021-01843-8
    Read this paper
  • Colozza G. Purified Bighead protein efficiently promotes head development in the South African clawed frog, Xenopus laevis. MicroPubl Biol. 2021,2021. doi: 10.17912/micropub.biology.000347
    Read this paper

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Figure 1. Western blot analysis of C-Myc/MYC using anti-C-Myc/MYC antibody (A00026-1). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample under reducing conditions. Lane 1: human Raji whole cell lysates, Lane 2: human K562 whole cell lysates, Lane 3: rat brain tissue lysates, Lane 4: rat C6 whole cell lysates, Lane 5: mouse brain tissue lysates, Lane 6: mouse NIH/3T3 whole cell lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocked the membrane with 5% non-fat milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-C-Myc/MYC antigen affinity purified polyclonal antibody (Catalog # A00026-1) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for C-Myc/MYC at approximately 65 kDa. The expected band size for C-Myc/MYC is at 65 kDa.
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