C Reactive Protein antibody [CRP-8]

GeneTex

C Reactive Protein antibody [CRP-8]

7

The antibody recognizes an epitope located on the 24 kDa subunit of denatured and reduced CRP. It does not cross-react with human serum amyloid P component (SAP), human haptoglobin, human α1-acid glycoprotein, human IgG, and CRP from Limulus.

WB: 1:200. ELISA: 1:40,000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Research Use Only

Monoclonal

CRP-8

Unconjugated

Liquid

CRP

C-reactive protein

C-reactive protein; C-reactive protein, pentraxin-related; pentraxin 1; PTX1

Mouse

IgG1

C-reactive protein

C Reactive Protein is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a pentraxin (cyclic pentameric protein) compound of five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa), that are bound noncovalently to form the physiologic CRP molecule (m.w. 117.5 kDa). C Reactive Protein mediates activities associated with preimmune nonspecific host resistance. It is opsonic, an initiator of the classical complement cascade and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. Studies have revealed that among other markers of inflammation, CRP shows the strongest association with cardiovascular events. Many clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. Measurements of C-reactive protein (hsCRP) in the patients with ischemic heart disease provide a novel method for detecting individuals at high risk of plaque rapture.

-20°C or -80°C,2°C to 8°C

12352203