C-VGB3
HY-P10833
Product group Proteins / Signaling Molecules
Overview
- SupplierMedChem Express
- Product NameC-VGB3
- Delivery Days Customer5
- CertificationResearch Use Only
- Scientific DescriptionC-VGB3 is a selective vascular endothelial growth factor receptor 2 (VEGFR2) antagonist, which inhibits VEGFR2-mediated PI3K/AKT/mTOR and PLCgamma/ERK1/2 signaling pathways. C-VGB3 binds to the extracellular domain of VEGFR2, blocking ligand-receptor interaction and inducing apoptosis in endothelial and tumor cells through both intrinsic (involving Bcl2 family and caspases) and extrinsic (death receptor-mediated) pathways. C-VGB3 is promising for research of angiogenesis-related cancers, such as breast cancer[1][2].
- UNSPSC41116100