C4 / C4b antibody [N1N2-2], N-term

GeneTex

C4 / C4b antibody [N1N2-2], N-term

9

WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

0.52 mg/ml

Unconjugated

Liquid

C4A

complement C4A (Rodgers blood group)

acidic C4; acidic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C4; C4A anaphylatoxin; C4A2; C4A3; C4A4; C4A6; C4AD; C4S; CO4; complement C4-A; complement component 4A (Rodgers blood group); CPAMD2; MHC class III region complement; RG; Rodgers form of C4

Rabbit

IgG

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. [provided by RefSeq]

Human

-20°C or -80°C,2°C to 8°C

12352203