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CAB39 Polyclonal Antibody

RD76966A
Reddot Biotech
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
TargetCAB39
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    CAB39 Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    Western Blot, ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.7 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID51719
  • Target name
    CAB39
  • Target description
    calcium binding protein 39
  • Target synonyms
    calcium-binding protein 39; CGI-66; MO25; MO25alpha
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha). STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK).
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203

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