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Cabozantinib (XL184)

S1119
Selleck Chemicals
Estimated Purity...
Product group Chemicals
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Overview

  • Supplier
    Selleck Chemicals
  • Product Name
    Cabozantinib (BMS-907351) [849217-68-1]
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Estimated Purity
    ...
  • Scientific Description
    Cabozantinib (XL184) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3beta/NF-kappaB signaling pathway.
  • Storage Instruction
    -80°C
  • UNSPSC
    51202000

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