Calyculin A [101932-71-2]

TargetMol Chemicals

Calyculin A

44

101932-71-2

Chemical

Research Use Only

Calyculin A

98%

C50H81N4O15P

1009.17

Calyculin A ((-)-Calyculin A), a toxicant in the Japanese marine sponge CDiscodermia calyxC, is a selective and potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A), inducing hyperactivation of cryopreserved bovine spermatozoa and inhibiting radiation-induced gammaH2AX DNA repair disease in human lymphocytes. gammaH2AX DNA repair foci in human lymphocytes.

3 years

C[C@@]1(C)[C@@]2(O[C@]([C@H](C[C@@H]([C@@H]([C@@H]([C@@H](/C=C(/C(=C/C=C/C(=C\C#N)/C)/C)\C)C)O)C)O)OC)([C@@H]1OP(=O)(O)O)[H])O[C@@H](C/C=C/C=3N=C([C@H](CCNC([C@H]([C@H]([C@H](COC)N(C)C)O)O)=O)C)OC3)[C@@H](C)[C@H](O)C2

-20°C

12352200