Capmatinib (dihydrochloride) [1197376-85-4]
HY-13404A
CAS Number1197376-85-4
Product group Chemicals
Molecular Weight485.34
Overview
- SupplierMedChem Express
- Product NameCapmatinib (dihydrochloride) [1197376-85-4]
- Delivery Days Customer10
- CAS Number1197376-85-4
- CertificationResearch Use Only
- Molecular FormulaC23H19Cl2FN6O
- Molecular Weight485.34
- Scientific DescriptionCapmatinib (INC280; INCB28060) dihydrochloride is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib dihydrochloride can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride is largely metabolized by CYP3A4 and aldehyde oxidase[1][2][3].
- SMILESO=C(NC)C1=CC=C(C2=NN3C(N=C2)=NC=C3CC4=CC=C5N=CC=CC5=C4)C=C1F.Cl.Cl
- UNSPSC12352200