Capmatinib dihydrochloride hydrate

AbMole BioScience

Capmatinib dihydrochloride hydrate

9

1865733-40-9

Chemical

Research Use Only

C23H21Cl2FN6O2

503.00

Capmatinib dihydrochloride hydrate is a potent, orally active, selective, ATP-competitive c-Met kinase inhibitor (IC50=0.13 nM) that inhibits the phosphorylation of c-MET, as well as downstream effector proteins of the c-MET pathway, such as ERK1/2, AKT, FAK, In addition, Capmatinib dihydrochloride hydrate effectively inhibited the proliferation and migration of c-Met-dependent tumor cells, induced apoptosis, and demonstrated antitumor activity in a mouse model of tumor. Capmatinib dihydrochloride hydrate is mainly metabolized by CYP3A4 and aldehyde oxidase.

4°C, protect from light, dry, sealed

12352200