Capmatinib (dihydrochloride hydrate) (Standard) [1865733-40-9]
HY-13404CR
Product group Assays
Overview
- SupplierMedChem Express
- Product NameCapmatinib (dihydrochloride hydrate) (Standard) [1865733-40-9]
- Delivery Days Customer999
- CertificationResearch Use Only
- Scientific DescriptionCapmatinib (dihydrochloride hydrate) (Standard) is the analytical standard of Capmatinib (dihydrochloride hydrate). This product is intended for research and analytical applications. Capmatinib (INC280; INCB28060) dihydrochloride hydrate is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib dihydrochloride hydrate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride hydrate is largely metabolized by CYP3A4 and aldehyde oxidase[1][2][3].
- UNSPSC41116100