Capmatinib (Standard) [1029712-80-8]
HY-13404R
Product group Assays
Overview
- SupplierMedChem Express
- Product NameCapmatinib (Standard) [1029712-80-8]
- Delivery Days Customer5
- CAS Number1029712-80-8
- CertificationResearch Use Only
- Molecular FormulaC23H17FN6O
- Molecular Weight412.42
- Scientific DescriptionCapmatinib (Standard) is the analytical standard of Capmatinib. This product is intended for research and analytical applications. Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase[1][2][3].
- SMILESO=C(NC)C1=CC=C(C2=NN3C(N=C2)=NC=C3CC4=CC=C5N=CC=CC5=C4)C=C1F
- UNSPSC41116135