CARD14 antibody

GeneTex

CARD14 antibody

9

Western Blot

Research Use Only

Polyclonal

Unconjugated

CARD14

caspase recruitment domain family member 14

bcl10-interacting maguk protein 2; BIMP2; CARD-containing MAGUK protein 2; CARMA2; caspase recruitment domain-containing protein 14; PRP; PSORS2; PSS1

Chicken

IgY

Caspase recruitment domain-containing protein 14

Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family. a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family. which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10. a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells. this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported.

Human

-20°C or -80°C,2°C to 8°C

12352203