Cardamonin [19309-14-9]

Chemodex

Cardamonin [19309-14-9]

10

9

19309-14-9

Research Use Only

>98%

Warning

C16H14O4

270.28

Cardamonin is a calchone from Aplinia species (zingiberaceous plant species) with anti-cancer and anti-inflammatory, anti-nociceptive activity. Cardamonin suppresses NF-kappa nuclear translocation and Ik-Ba phosphorylation. It has been shown to suppress nitric oxide and prostaglandin E2 synthesis, to suppress cyclooxygenase-2 expression, and to inhibit NF-kappa signaling. It induces apoptosis in cancer cells, suppresses melanogenesis by inhibition of Wnt/beta-catenin signaling and ameliorates insulin resistance. It has been shown to induce autophagy and an antiproliferative effect through JNK activation. It is an hTRPA1 antagonist and shows also anti-parasitic activity. Also shown inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. - Chemical. CAS: 19309-14-9. Formula: C16 H14 O4. MW: 270.28. Cardamonin is a calchone from Aplinia species (zingiberaceous plant species) with anti-cancer and anti-inflammatory, anti-nociceptive activity. Cardamonin suppresses NF-kappa nuclear translocation and Ik-Ba phosphorylation. It has been shown to suppress nitric oxide and prostaglandin E2 synthesis, to suppress cyclooxygenase-2 expression, and to inhibit NF-kappa signaling. It induces apoptosis in cancer cells, suppresses melanogenesis by inhibition of Wnt/beta-catenin signaling and ameliorates insulin resistance. It has been shown to induce autophagy and an antiproliferative effect through JNK activation. It is an hTRPA1 antagonist and shows also anti-parasitic activity. Also shown inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.

O=C(C1=C(OC)C=C(O)C=C1O)/C=C/C2=CC=CC=C2

RT

3077

12352200