Carfilzomib (PR-171)

Selleck Chemicals

Carfilzomib (PR-171) [868540-17-4]

9

868540-17-4

Research Use Only

...

Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the beta5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagy and induces cell apoptosis.

-80°C

51202000