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Casein Kinase 2 alpha antibody

GTX107897
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetCSNK2A1
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Overview

  • Supplier
    GeneTex
  • Product Name
    Casein Kinase 2 alpha antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.62 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID1457
  • Target name
    CSNK2A1
  • Target description
    casein kinase 2 alpha 1
  • Target synonyms
    casein kinase 2, alpha 1 polypeptide; casein kinase II alpha 1 polypeptide pseudogene; casein kinase II alpha 1 subunit; casein kinase II subunit alpha; CK2 catalytic subunit alpha; CK2A1; Cka1; Cka2; CKII; OCNDS; protein kinase CK2
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site.
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  • Effects of Casein Kinase 2 Alpha 1 Gene Expression on Mice Liver Susceptible to Type 2 Diabetes Mellitus and Obesity. Lan YC et al., 2020, Int J Med Sci
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  • Modulation of Heat Shock Factor 1 Activity through Silencing of Ser303/Ser307 Phosphorylation Supports a Metabolic Program Leading to Age-Related Obesity and Insulin Resistance. Jin X et al., 2018 Sep 15, Mol Cell Biol
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  • WITHDRAWN: Abrogation of heat shock factor 1 (Hsf1) phosphorylation deregulates its activity and lowers activation threshold, leading to obesity in mice. Jin X et al., 2017 Jul 19, J Biol Chem
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  • MRE11 stability is regulated by CK2-dependent interaction with R2TP complex. von Morgen P et al., 2017 Aug 24, Oncogene
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  • Nrf2/ARE Pathway Involved in Oxidative Stress Induced by Paraquat in Human Neural Progenitor Cells. Dou T et al., 2016, Oxid Med Cell Longev
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