Catalase [9001-05-2]

Athens Research

Catalase [9001-05-2]

9

Cell Culture Media, Protein Chemistry Studies, Enzymatic Activity Assays

9001-05-2

Research Use Only

≥95% by SDS-PAGE

Catalase

Human catalase is a tetrameric enzyme composed of four identical subunits, each containing a heme group coordinated by tyrosine at the active site. This iron-dependent oxidoreductase catalyzes the rapid decomposition of hydrogen peroxide (2H2O2→2H2O+O2). Beyond its primary antioxidant role, catalase works with superoxide dismutase and glutathione peroxidase to neutralize reactive oxygen species (ROS), protecting cellular components from oxidative damage. Genetic mutations in the CAT gene cause acatalasemia, characterized by severe catalase deficiency (less then10% activity) linked to oral ulcerations, gangrene, and heightened susceptibility to type 2 diabetes due to pancreatic bèta-cell damage. Polymorphisms in catalase (e.g., -262 C/T promoter variant) correlate with oxidative stress-related pathologies, including hypertension, Alzheimer's disease, and vitiligo. Elevated catalase activity occurs in atherosclerosis and certain cancers as a compensatory response to chronic oxidative stress. Therapeutically, catalase is explored for treating ischemia-reperfusion injury through gene therapy and nanoparticle delivery systems. Recent clinical trials investigate catalase mimetics and combination antioxidant therapies for neurodegenerative disorders, leveraging its neuroprotective effects against amyloid-bèta toxicity.

more then 1 year

Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests

≤ -80° C

41116100