Cathepsin H [9047-22-7]

Athens Research

Cathepsin H [9047-22-7]

9

Cancer, Alzheimer's, Parkinson's, In Vitro Diagnostic

9047-22-7

Research Use Only

≥ 90% by SDS-PAGE

Pro-cathepsin H

Cathepsin H (CatH) is a lysosomal cysteine protease distinguished by its unique dual aminopeptidase and endopeptidase activities. Unlike other cathepsins, it includes a disulfide-linked mini-chain that anchors substrate N-termini via electrostatic interactions, enabling sequential cleavage of N-terminal basic residues (Arg/Lys). This exopeptidase function, optimal at neutral pH, facilitates its role in extracellular spaces, while its endopeptidase activity at acidic pH (4.5–5.5) supports lysosomal protein degradation. Clinically, CatH overexpression correlates with aggressive tumor phenotypes. In colorectal cancer, CatH activity is elevated promoting metastasis via extracellular matrix remodeling. Serum CatH levels more then45 ng/mL serve as a prognostic marker for melanoma metastasis and reduced survival. Conversely, decreased CatH in head/neck squamous carcinomas and polycystic kidney disease suggests tissue-specific regulatory roles. In Alzheimer’s disease, CatH contributes to amyloid-bèta plaque formation by cleaving tau and amyloid precursor proteins, while in Parkinson’s models, it degrades alfa-synuclein aggregates. Therapeutically, CatH’s role in neuropeptide processing (e.g., enkephalin and galanin biosynthesis) highlights its potential in pain management and neurodegenerative therapies. Inhibitors targeting its active site (e.g., E-64) reduce tumor invasion in preclinical models, while pH-selective compounds (Z-Arg-NHMec) spare lysosomal functions. Diagnostic applications leverage its elevated expression in gliomas and breast cancers for early detection and stratification. These multifunctional roles position CatH as a critical node in both lysosomal proteostasis and disease pathogenesis.

more then 1 year

Prepared from liver shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

≤ -80° C

41116100