Cav alpha 2/delta 2 antibody

GeneTex

Cav alpha 2/delta 2 antibody

9

WB: 1:2000. ICC/IF: 1:10-1:50. IHC-P: 1:10-1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

Unconjugated

CACNA2D2

calcium voltage-gated channel auxiliary subunit alpha2delta 2

CACNA2D, CASVDD, voltage-dependent calcium channel subunit alpha-2/delta-2, alpha 2 delta calcium channel subunit, alpha2delta-2, calcium channel, voltage-dependent, alpha 2/delta subunit 2, gene 26, voltage-gated calcium channel subunit alpha-2/delta-2

Rabbit

IgG

Voltage-dependent calcium channel subunit alpha-2/delta-2

Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

-20°C or -80°C,2°C to 8°C

12352203