Bio-Connect

CAY10526 [938069-71-7]

HY-118119
MedChem Express
CAS Number938069-71-7
Product group Chemicals
Estimated Purity99.12
Molecular Weight311.16
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Overview

  • Supplier
    MedChem Express
  • Product Name
    CAY10526 [938069-71-7]
  • Delivery Days Customer
    10
  • CAS Number
    938069-71-7
  • Certification
    Research Use Only
  • Estimated Purity
    99.12
  • Molecular Formula
    C12H7BrO3S
  • Molecular Weight
    311.16
  • Scientific Description
    CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC50[1].
  • SMILES
    O=C1C(Br)=C(C(O1)O)C2=CC3=CC=CC=C3S2
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200