CB096 [108883-90-5]

MedChem Express

CB096 [108883-90-5]

5

108883-90-5

Research Use Only

98.72

C14H11N3O4

285.25

CB096 binds the 5CGG/3GGC internal loop structure of r(G4C2)exp RNA, interrupts its gain-of-function mechanism, and thus results in the regulation of nucleolar focusing, RNA splicing defects, RNA metabolism, nucleocytoplasmic transport dysfunction, and toxic dipeptide repeats (DPRs) generated by RNA translation. CB096 inhibits the RAN translation with an IC50 of 20 microM in HEK293T cells[1].

OC1=CC=C(C2=NC3=CC=C([N+]([O-])=O)C=C3N2)C=C1OC

2°C to 8°C

12352200