CBFA2T2 Polyclonal Antibody

Reddot Biotech

CBFA2T2 Polyclonal Antibody

5

Western Blot, ELISA

Research Use Only

Polyclonal

1.26 mg/ml

Unconjugated

CBFA2T2

CBFA2/RUNX1 partner transcriptional co-repressor 2

EHT, MTGR1, ZMYND3, p85, protein CBFA2T2, CBFA2/RUNX1 translocation partner 2, ETO homolog on chromosome 20, ETO homologous on chromosome 20, MTG8-like protein, MTG8-related protein 1, core-binding factor, runt domain, alpha subunit 2; translocated to, 2, myeloid translocation gene-related protein 1, myeloid translocation-related protein 1

Rabbit

IgG

Protein CBFA2T2

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5-region of the RUNX1 (AML1) gene fused to the 3-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. - This is a CBFA2T2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

Human, Mouse

-20°C

41116161