CBL0137 [1197996-80-7]

TargetMol Chemicals

CBL0137 [1197996-80-7]

9

1197996-80-7

Chemical

Research Use Only

CBL0137

99.57%

C21H24N2O2

336.43

CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 microM) and inhibits NF-kappaB (EC50: 0.47 microM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-kappaB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preClinicalal models of pancreatic cancer.

3 years

C(CNC(C)C)N1C=2C(C=3C1=CC=C(C(C)=O)C3)=CC(C(C)=O)=CC2

-20°C

12352200