CBL0137 hydrochloride [1197397-89-9]
T4361
CAS Number1197397-89-9
Product group Chemicals
Estimated Purity99.35%
Molecular Weight372.88
Overview
- SupplierTargetMol Chemicals
- Product NameCBL0137 hydrochloride
- Delivery Days Customer4
- CAS Number1197397-89-9
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameCBL0137 hydrochloride
- Estimated Purity99.35%
- Molecular FormulaC21H25ClN2O2
- Molecular Weight372.88
- Scientific DescriptionCBL0137 hydrochloride (Curaxin-137 hydrochloride) is an inhibitor of the histone chaperone FACT, which also activates p53 and inhibits NF-kappaB with EC50 values of 0.37 and 0.47 microM, respectively. CBL0137 hydrochloride functionally inactivates the complex that promotes chromatin transcription (FACT), thereby driving effects on p53 and NF-kappaB and promoting cancer cell death, and when used in combination with cisplatin, CBL0137 hydrochloride has potent anticancer activity against SCLC.
- Shelf life instruction3 years
- SMILESCl.CC(C)NCCn1c2ccc(cc2c2cc(ccc12)C(C)=O)C(C)=O
- Storage Instruction-20°C
- UNSPSC12352200
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