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CC-99677 [1887069-10-4]

CC-99677 [1887069-10-4]

T39321
TargetMol Chemicals
CAS Number1887069-10-4
DownloadMSDS
Product group Chemicals
Estimated Purity99.87%
Molecular Weight469.94
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    CC-99677 [1887069-10-4]
  • Delivery Days Customer
    9
  • CAS Number
    1887069-10-4
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    CC-99677
  • Estimated Purity
    99.87%
  • Molecular Formula
    C22H20ClN5O3S
  • Molecular Weight
    469.94
  • Scientific Description
    CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.CC-99677 in Rat experiments demonstrated potency in both biochemical (IC 50 =156.3 nM) and cellular assays (EC 50 =89 nM).
  • Shelf life instruction
    3 years
  • SMILES
    CCOCc1cnc(Cl)nc1Oc1ccc2c3c4NC[C@@H](C)NC(=O)c4sc3ccc2n1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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