Gamcemetinib

MedChem Express

Gamcemetinib [1887069-10-4]

5

1887069-10-4

Research Use Only

99.06

C22H20ClN5O3S

469.94

Gamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). Gamcemetinib is extracted from patent WO2020236636, compound 1[1].

O=C1C2=C(NC[C@H](N1)C)C3=C(S2)C=CC4=NC(OC5=NC(Cl)=NC=C5COCC)=CC=C34

-20°C,2°C to 8°C

12352200