CCDC98 antibody

GeneTex

CCDC98 antibody

9

WB: 1 microg/mL. IHC-P: 5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

ABRAXAS1

abraxas 1, BRCA1 A complex subunit

ABRA1, CCDC98, FAM175A, BRCA1-A complex subunit Abraxas 1, abraxas protein, coiled-coil domain containing 98, family with sequence similarity 175 member A

Rabbit

IgG

BRCA1-A complex subunit Abraxas 1

CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.

-20°C or -80°C,2°C to 8°C

12352203