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CCL2 Protein, Human, Recombinant

CCL2 Protein, Human, Recombinant

TMPJ-00009
TargetMol Chemicals
DownloadMSDS
Product group Proteins / Signaling Molecules
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    CCL2 Protein, Human, Recombinant
  • Delivery Days Customer
    16
  • Certification
    Research Use Only
  • Scientific Description
    The chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemoattractant protein (MCP)-1 and small inducible cytokine A2 (SCYA2)), is a small cytokine that belongs to the CC chemokine family responsible for monocyte attraction. Its cognate receptor, CCR2, play a critical role in regulating nociceptive processes during neuropathic pain. Both CCL2 and CCR2 are implicated in induction of autoimmunity. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. Recently research also showed that CCL2 might be useful as a biomarker of fibrosis as well as a target for therapeutic intervention.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352202

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The chemotactic effect of GTX00415-pro Human MCP1 / CCL2 protein (active). Upper: (A) THP-1 cells were seeded into the upper chambers and serum free RPMI-1640 without MCP-1 was added in lower chamber, then cells in lower chamber were observed at low magnification (x100) after incubation for 3hrs. (B) THP-1 cells were seeded into the upper chambers and serum free RPMI-1640 with 25 ng/ml MCP-1 was added in lower chamber, then cells in lower chamber were observed at low magnification (x100) after incubation for 3hrs. (C) THP-1 cells were seeded into the upper chambers and serum free RPMI-1640 with 50 ng/ml MCP-1 was added in lower chamber, then cells in lower chamber were observed at low magnification (x100) after incubation for 3hrs. Lower: The number of migrated cells were counted at high magnification (x400) randomly (five fields for each filter).
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