CCM2 blocking peptide

GeneTex

CCM2 blocking peptide

9

Research Use Only

CCM2

CCM2 scaffold protein

C7orf22, OSM, PP10187, cerebral cavernous malformations 2 protein, CCM2 scaffolding protein, cerebral cavernous malformation 2, malcavernin, osmosensing scaffold for MEKK3

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]

-20°C or -80°C,2°C to 8°C

41116100

Human