CCT128930 [885499-61-6]

MedChem Express

CCT128930 [885499-61-6]

10

885499-61-6

Research Use Only

99.69

C18H20ClN5

341.84

CCT128930 is a ATP-competitive and selective inhibitor of AKT (IC50=6 nM for AKT2). CCT128930 has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC50=120 nM). Antitumor activity.

ClC1=CC=C(C=C1)CC2(CCN(CC2)C3=NC=NC4=C3C=CN4)N

-20°C,2°C to 8°C

12352200