CCT367766 (formic)

MedChem Express

CCT367766 (formic)

10

Research Use Only

98.02

C50H50ClN7O13

992.42

CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon -based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC 50 value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with K d values of 55 nM and 120 nM, respectively. CCT367766 formic provides a potential chemical tool to study a largely unexplored protein [1] .

O=C(C1=CC=C2N=C(CN3CCN(CCOCCOCCOC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)CC3)C=CC2=C1)NC7=CC(NC(C8=CC=C(OCCO9)C9=C8)=O)=CC=C7Cl.OC=O

-20°C

12352200