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CD11b antibody [2LPM19c]

Research Use Only
GTX72023
GeneTex
ApplicationsFlow Cytometry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking, Other Application
Product group Antibodies
ReactivityHamster, Human
TargetITGAM
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Overview

  • Supplier
    GeneTex
  • Product Name
    CD11b antibody [2LPM19c]
  • Delivery Days Customer
    9
  • Application Supplier Note
    For a three-step avidin-biotin complex system, a dilution of 1:50 to 1:100 may be used as a guideline. Dilute according to the particular application being used. In general, the 0.05M Borate pH 8.0 containing 0.15M Sodium Chloride, 0.05% Sodium Azide, is a good diluent to use with most antibodies. Optimal dilutions/concentrations should be determined by the researcher.
  • Applications
    Flow Cytometry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking, Other Application
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    2LPM19c
  • Concentration
    0.1 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID3684
  • Target name
    ITGAM
  • Target description
    integrin subunit alpha M
  • Target synonyms
    antigen CD11b (p170); CD11 antigen-like family member B; CD11B; cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; CR-3 alpha chain; CR3A; integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit); leukocyte adhesion receptor MO1; MAC-1; MAC1A; macrophage antigen alpha polypeptide; macrophage-1 antigen alpha subunit; MO1A; neutrophil adherence receptor alpha-M subunit; SLEB6
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP11215
  • Protein Name
    Integrin alpha-M
  • Scientific Description
    This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
  • Reactivity
    Hamster, Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense. Wolf D et al., 2018 Feb 6, Nat Commun
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