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ProductsBack/CD11b antibody [ICRF44] (FITC)
FACS analysis of human peripheral blood monocytes using GTX00481-06 CD11b antibody [ICRF44] (FITC). Solid line : Primary antibody Dashed line : FITC mouse IgG1 isotype control Antibody amount : 1 μg
FACS analysis of human peripheral blood monocytes using GTX00481-06 CD11b antibody [ICRF44] (FITC). Solid line : Primary antibody Dashed line : FITC mouse IgG1 isotype control Antibody amount : 1 μg
FACS analysis of human peripheral blood monocytes using GTX00481-06 CD11b antibody [ICRF44] (FITC). Solid line : Primary antibody Dashed line : FITC mouse IgG1 isotype control Antibody amount : 1 μg

CD11b antibody [ICRF44] (FITC)

GTX00481-06
GeneTex
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman, Monkey, Porcine, Primate
TargetITGAM
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Overview

  • Supplier
    GeneTex
  • Product Name
    CD11b antibody [ICRF44] (FITC)
  • Delivery Days Customer
    9
  • Application Supplier Note
    FACS: 1 microg (5 microl) for 105-108 cells in 100 microl sample per test. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    ICRF44
  • Concentration
    0.2 mg/ml
  • Conjugate
    FITC
  • Gene ID3684
  • Target name
    ITGAM
  • Target description
    integrin subunit alpha M
  • Target synonyms
    CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6, integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, antigen CD11b (p170), cell surface glycoprotein MAC-1 subunit alpha, complement component 3 receptor 3 subunit, integrin, alpha M (complement component 3 receptor 3 subunit), leukocyte adhesion receptor MO1, macrophage antigen alpha polypeptide, macrophage-1 antigen alpha subunit, neutrophil adherence receptor alpha-M subunit
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP11215
  • Protein Name
    Integrin alpha-M
  • Scientific Description
    This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
  • Reactivity
    Human, Monkey, Porcine, Primate
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Short JD, Tavakoli S, Nguyen HN, et al. Dyslipidemic Diet-Induced Monocyte "Priming" and Dysfunction in Non-Human Primates Is Triggered by Elevated Plasma Cholesterol and Accompanied by Altered Histone Acetylation. Front Immunol. 2017,8:958. doi: 10.3389/fimmu.2017.00958
    Read this paper
  • Valle YL, Almalki SG, Agrawal DK. Vitamin D machinery and metabolism in porcine adipose-derived mesenchymal stem cells. Stem Cell Res Ther. 2016,7(1):118. doi: 10.1186/s13287-016-0382-4
    Read this paper
  • Douthwaite JA, Sridharan S, Huntington C, et al. Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1. MAbs. 2015,7(1):152-66. doi: 10.4161/19420862.2014.985158
    Read this paper
  • Prosniak M, Harshyne LA, Andrews DW, et al. Glioma grade is associated with the accumulation and activity of cells bearing M2 monocyte markers. Clin Cancer Res. 2013,19(14):3776-86. doi: 10.1158/1078-0432.CCR-12-1940
    Read this paper
  • Feng C, Zhang L, Almulki L, et al. Endogenous PMN sialidase activity exposes activation epitope on CD11b/CD18 which enhances its binding interaction with ICAM-1. J Leukoc Biol. 2011,90(2):313-21. doi: 10.1189/jlb.1210708
    Read this paper
  • Jerke U, Rolle S, Dittmar G, et al. Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation. J Biol Chem. 2011,286(9):7070-81. doi: 10.1074/jbc.M110.171256
    Read this paper
  • Chang WL, Barry PA. Attenuation of innate immunity by cytomegalovirus IL-10 establishes a long-term deficit of adaptive antiviral immunity. Proc Natl Acad Sci U S A. 2010,107(52):22647-52. doi: 10.1073/pnas.1013794108
    Read this paper
  • Moreau A, Hill M, Thébault P, et al. Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase-1 in rodents and in nonhuman primates. FASEB J. 2009,23(9):3070-7. doi: 10.1096/fj.08-128173
    Read this paper
  • Sengoku K, Takuma N, Miyamoto T, et al. Integrins are not involved in the process of human sperm-oolemmal fusion. Hum Reprod. 2004,19(3):639-44.
    Read this paper
  • David A, Kacher Y, Specks U, et al. Interaction of proteinase 3 with CD11b/CD18 (beta2 integrin) on the cell membrane of human neutrophils. J Leukoc Biol. 2003,74(4):551-7.
    Read this paper

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