CD11b antibody [MEM-170] (Azide Free)

GeneTex

CD11b antibody [MEM-170] (Azide Free)

9

This antibody recognizes CD11b antigen (Mac-1alpha), a 165-170 kDa transmembrane protein type 1 mainly expressed on monocytes, granulocytes and NK-cells. The antibody blocks (not completely) Mac-1-mediated neutrophil binding to fibrinogen.

Functional Assay, Flow Cytometry

Research Use Only

Monoclonal

MEM-170

1 mg/ml

Unconjugated

ITGAM

integrin subunit alpha M

antigen CD11b (p170); CD11 antigen-like family member B; CD11B; cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; CR-3 alpha chain; CR3A; integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit); leukocyte adhesion receptor MO1; MAC-1; MAC1A; macrophage antigen alpha polypeptide; macrophage-1 antigen alpha subunit; MO1A; neutrophil adherence receptor alpha-M subunit; SLEB6

Mouse

IgG1

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Human

2°C to 8°C

12352203