CD123 [IL-3Ralpha] (human)-muIg Fusion Protein (Biotin)

Ancell Corporation

CD123 [IL-3Ralpha] (human)-muIg Fusion Protein (Biotin)

10

Research Use Only

0.5 mg/ml

Biotin

IL3RA

interleukin 3 receptor subunit alpha

CD123, IL-3R-alpha, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra, interleukin-3 receptor subunit alpha, CD123 antigen, IL-3 receptor subunit alpha, IL-3R subunit alpha, interleukin 3 receptor, alpha (low affinity)

Interleukin-3 receptor subunit alpha

Human CD123 (Interleukin-3 Receptor alpha) is a 70kDa type I transmembrane molecule, and is the low affinity receptor for the cytokine IL-3, which can stimulate proliferation or differentiation. When paired in a heterodimer with CD131 (IL-3Rbeta), it binds IL-3 with much higher affinity. CD123 is found on myeloid precusors, stem cells, a subset of T cells, some B cells, megakaryocytes, basophils, monocytes and epithelial cells. CD123 is present at high levels on many hematologic malignancies, and antibodies and CAR T cells against CD123 have been used successfully to combat acute myeloid leukemia (AML). - Recombinant Protein. A soluble molecule consisting of the extracellular domain of mature human CD123 fused to murine IgG2a Fc. 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl, 5% Glycerol, 0.2% BSA, 0.04% Sodium Azide. Human CD123 (Interleukin-3 Receptor alpha) is a 70kDa type I transmembrane molecule, and is the low affinity receptor for the cytokine IL-3, which can stimulate proliferation or differentiation. When paired in a heterodimer with CD131 (IL-3Rbeta), it binds IL-3 with much higher affinity. CD123 is found on myeloid precusors, stem cells, a subset of T cells, some B cells, megakaryocytes, basophils, monocytes and epithelial cells. CD123 is present at high levels on many hematologic malignancies, and antibodies and CAR T cells against CD123 have been used successfully to combat acute myeloid leukemia (AML).

2°C to 8°C

41116100

Human