CD25 Antibody / IL2RA

Biorbyt

CD25 Antibody / IL2RA

10

Optimal dilution of the CD25 antibody should be determined by the researcher.

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Immunohistochemistry (FFPE): 2-4ug/ml for 30 min at RT IHC-P

Research Use Only

Monoclonal

IL2RA/2395

Unconjugated

IL2RA

interleukin 2 receptor subunit alpha

CD25, IDDM10, IL2R, IMD41, TCGFR, p55, interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2R subunit alpha, TAC antigen, interleukin 2 receptor, alpha

Mouse

IgG2b

Interleukin-2 receptor subunit alpha

Recognizes a protein of 55 kDa, identified as CD25. It is expressed on activated T- and B-cells and activated monocytes/macrophages. With respect to lymphomas, CD25 is present on malignant cells of Hodgkins disease, HTLV-1+ adult T-cell leukemia, cutaneous T-cell lymphoma, and hair cell leukemia. Increased levels of soluble CD25 are observed in the leukemias/lymphomas and inflammatory/ autoimmune diseases. CD25 molecule alone appears to function as a low affinity receptor and associates with CD122 (IL-2R b-chain, p75) and CD132 (common g-chain) to form the high affinity IL-2 receptor complex. CD25 antibodies detect three epitope regions, A, B and C. This mAb recognizes the epitope B, which is located at residue 3-104 of CD25 and does not block IL-2 binding to CD25.

Human

-20°C,2°C to 8°C

12352203