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CD278 [ICOS] (human):Fc (human) (rec.)(non-lytic)

Research Use Only
CHI-HF-220ICOS
Chimerigen Laboratories
Product group Proteins / Signaling Molecules
Price on request
Packing Size
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Overview

  • Supplier
    Chimerigen Laboratories
  • Product Name
    CD278 [ICOS] (human):Fc (human) (rec.) (non-lytic)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Scientific Description
    CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. - Protein. The extracellular domain of human CD278 [ICOS] (aa 21-139) is fused to the N-terminus of the Fc region of a mutant human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/microg protein (LAL test; Lonza). Lyophilized from 0.2microm-filtered solution in PBS. Purity: >98% (SDS-PAGE). CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352202