CD32 (Fc Gamma RIIa)(FCGR2A/479), CF740 conjugate, 0.1mg/mL

Biotium

CD32 (Fc Gamma RIIa)(FCGR2A/479), CF740 conjugate, 0.1mg/mL

16

Research Use Only

Monoclonal

FCGR2A/479

0.1 mg/ml

Other Conjugate

FCGR2A

Fc gamma receptor IIa

CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, FcgammaRIIa, IGFR2, low affinity immunoglobulin gamma Fc region receptor II-a, Fc fragment of IgG receptor IIa, Fc fragment of IgG, low affinity IIa, receptor (CD32), Fc gamma receptor RIIa3, Immunoglobulin G Fc receptor II, fc-gamma-RIIa, fcRII-a, igG Fc receptor II-a

IgG2b

Low affinity immunoglobulin gamma Fc region receptor II-a

This MAb binds most strongly to the IIa isoforms of CD32 (FcRII), a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i. e. , IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

2°C to 8°C,RT

41116100