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ProductsBack/CD35 antibody [CR1/802]
IHC-P analysis of human tonsil tissue using GTX34504 CD35 antibody [CR1/802].
IHC-P analysis of human tonsil tissue using GTX34504 CD35 antibody [CR1/802].
IHC-P analysis of human tonsil tissue using GTX34504 CD35 antibody [CR1/802].

CD35 antibody [CR1/802]

GTX34504
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Monkey, Primate
TargetCR1
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Overview

  • Supplier
    GeneTex
  • Product Name
    CD35 antibody [CR1/802]
  • Delivery Days Customer
    9
  • Antibody Specificity
    Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1)/CD35. This MAb does not block CR1 activity. It is highly specific to CR1 and shows no cross-reaction with CR2.
  • Application Supplier Note
    ICC/IF: 1-2microg/ml. IHC-P: 1-2microg/ml for 30 minutes at RT. FACS: 1-2microg/106 cells. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    CR1/802
  • Concentration
    0.2 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID1378
  • Target name
    CR1
  • Target description
    complement C3b/C4b receptor 1 (Knops blood group)
  • Target synonyms
    C3b/C4b receptor; C3-binding protein; C3BR; C4BR; CD35; CD35 antigen; complement component (3b/4b) receptor 1 (Knops blood group); complement receptor 1; complement receptor type 1; KN; Knops blood group antigen
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP17927
  • Protein Name
    Complement receptor type 1
  • Scientific Description
    This gene is a member of the receptors of complement activation (RCA) family and is located in the cluster RCA region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human, Monkey, Primate
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203