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CD4 antibody [RPA-T4] (PE)

Research Use Only
GTX74819
GeneTex
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman, Primate
TargetCD4
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    CD4 antibody [RPA-T4] (PE)
  • Delivery Days Customer
    9
  • Antibody Specificity
    Epitope mapping studies have shown that antibodies, produced by clone RPA-T4, recognize an epitope within domain 1 of the extracellular region of the CD4 molecule.
  • Applications
    Flow Cytometry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    RPA-T4
  • Concentration
    0.1 mg/ml
  • Conjugate
    RPE
  • Gene ID920
  • Target name
    CD4
  • Target description
    CD4 molecule
  • Target synonyms
    CD4 antigen (p55); CD4 receptor; CD4mut; IMD79; OKT4D; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
  • Reactivity
    Human, Primate
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge. Stanley DA et al., 2014 Oct, Nat Med
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  • Loss of asparagine-linked glycosylation sites in variable region 5 of human immunodeficiency virus type 1 envelope is associated with resistance to CD4 antibody ibalizumab. Toma J et al., 2011 Apr, J Virol
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  • CIITA enhances HIV-1 attachment to CD4+ T cells leading to enhanced infection and cell depletion. Porter KA et al., 2010 Dec 1, J Immunol
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  • The length of and nonhydrophobic residues in the transmembrane domain of dengue virus envelope protein are critical for its retention and assembly in the endoplasmic reticulum. Hsieh SC et al., 2010 May, J Virol
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  • Effective activation alleviates the replication block of CCR5-tropic HIV-1 in chimpanzee CD4+ lymphocytes. Decker JM et al., 2009 Nov 10, Virology
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  • Modulation of CD1d-restricted NKT cell responses by CD4. Chen X et al., 2007 Dec, J Leukoc Biol
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  • CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells. Thedrez A et al., 2007 Jul 1, Blood
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  • Cardiac allograft vascular disease. Relationship to microvascular cell surface markers and inflammatory cell phenotypes on endomyocardial biopsy. Deng MC et al., 1995 Mar 15, Circulation
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