CD40L/CD154/TRAP, Mouse (HEK293, Fc)

MedChem Express

CD40L/CD154/TRAP, Mouse (HEK293, Fc)

10

Research Use Only

92.40

Cd40lg

CD40 ligand

CD154, CD40-L, Cd40l, HIGM1, IGM, IMD3, Ly-62, Ly62, T-BAM, TRAP, Tnfsf5, Tnlg8b, gp39, CD40 ligand, T-cell antigen Gp39, TNF-related activation protein, tumor necrosis factor ligand 8b, tumor necrosis factor ligand superfamily member 5

CD40 ligand

CD40L (CD154; TRAP) is a ligand to CD40/TNFRSF5, acts function by generating a costimulatory signal that up-regulates IL-4 synthesis[1]. CD40L is specifically expressed on activated CD4+ T-lymphocytes and involves in activation of NF-kappaB/MAPK pathway[2][3]. CD40L also involves in B cell differentiation, maturation, and apoptosis[4]. CD40L in mouse, cleaved into 2 chains of membrane form (1-260 a.a.) and soluble form (112-260 a.a.) which serves as a ligand for integrins (ITGA5:ITGB1 and ITGAV:ITGB3). CD40L/CD154/TRAP Protein, Mouse (HEK293, Fc) is expressed in HEK392 cells with N-terminal hFc-tag.

-20°C

41116100