CD40L/CD154/TRAP, Rhesus macaque (His)

MedChem Express

CD40L/CD154/TRAP, Rhesus macaque (His)

10

Research Use Only

CD40LG

CD40 ligand

CD40L, CD40 ligand, CD154 protein, CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome), CD40-L, tumor necrosis factor ligand superfamily member 5

CD40 ligand

CD40L (CD154; TRAP) is a ligand to CD40/TNFRSF5, acts function by generating a costimulatory signal that up-regulates IL-4 synthesis[1]. CD40L is specifically expressed on activated CD4+ T-lymphocytes and involves in activation of NF-kappaB/MAPK pathway[2][3]. CD40L also involves in B cell differentiation, maturation, and apoptosis[4]. CD40L in Rhesus macaque, cleaved into 2 chains of membrane form (1-261 a.a.) and soluble form (113-261 a.a.) which serves as a ligand for integrins (ITGA5:ITGB1 and ITGAV:ITGB3). CD40L/CD154/TRAP Protein, Rhesus macaque (His) has a total length of 218 amino acids (V44-L261), is expressed in E. coli cells with N-terminal 6*His-tag.

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