CD42b antibody [SZ2]

GeneTex

CD42b antibody [SZ2]

9

The molecular weight of the recognized antigen is 160 kDa. Reacts with glycoprotein Ib on megakaryocytesand platelets. Inhibits the ristocetin-dependent binding of Von Willebrand factor to platelets and ristocetininduced platelet agglutination. Inhibits p

FACS: 2 microg. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry

Research Use Only

Monoclonal

SZ2

0.20 mg/ml

Unconjugated

Liquid

GP1BA

glycoprotein Ib platelet subunit alpha

antigen CD42b-alpha; BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; glycoprotein Ib (platelet), alpha polypeptide; glycoprotein Ib platelet alpha subunit; GP1B; GP-Ib alpha; GPIbA; GPIbalpha; mutant platelet membrane glycoprotein Ib-alpha; platelet glycoprotein Ib alpha chain; platelet membrane glycoprotein 1b-alpha subunit; platelet membrane glycoprotein Ib-alpha; VWDP

Mouse

IgG1

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]

Human

-20°C or -80°C,2°C to 8°C

12352203