CD45 antibody [F10-89-4]
GTX76584
ApplicationsFlow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetPTPRC
Overview
- SupplierGeneTex
- Product NameCD45 antibody [F10-89-4]
- Delivery Days Customer9
- Antibody SpecificityThis antibody reacts with all forms of CD45.
- ApplicationsFlow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDF10-89-4
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID5788
- Target namePTPRC
- Target descriptionprotein tyrosine phosphatase receptor type C
- Target synonymsB220; CD45; CD45 antigen; CD45R; GP180; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, c polypeptide; receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen
- HostMouse
- IsotypeIgG2a
- Scientific DescriptionThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203
References
- The commonly used antimicrobial additive triclosan is a liver tumor promoter. Yueh MF et al., 2014 Dec 2, Proc Natl Acad Sci U S ARead more
- Isolation of hofbauer cells from human term placentas with high yield and purity. Tang Z et al., 2011 Oct, Am J Reprod ImmunolRead more
- Focal increases of fetal macrophages in placentas from pregnancies with histological chorioamnionitis: potential role of fibroblast monocyte chemotactic protein-1. Toti P et al., 2011 May, Am J Reprod ImmunolRead more