CD45R antibody [RA3-6B2] (FITC)

GeneTex

CD45R antibody [RA3-6B2] (FITC)

9

FACS: Use 0.25microg for 10^6 cells. IF: Use at a dilution of 1/1000. Optimal dilutions/concentrations should be determined by the end user.

Flow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry

Research Use Only

Monoclonal

RA3-6B2

0.5 mg/ml

FITC

Ptprc

protein tyrosine phosphatase, receptor type, C

B220; Cd45; CD45R; L-CA; leukocyte common antigen; loc; Ly-; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-; Lyt-4; receptor-type tyrosine-protein phosphatase C; T200

Rat

IgG2a

CD45R is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45R contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. CD45R also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Mouse

-20°C,2°C to 8°C

12352203