CD46 Antibody

Cusabio

CD46 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

CD46

CD46 molecule

AHUS2, MCP, MIC10, TLX, TRA2.10, membrane cofactor protein, CD46 antigen, complement regulatory protein, CD46 molecule, complement regulatory protein, antigen identified by monoclonal antibody TRA-2-10, complement membrane cofactor protein, measles virus receptor, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), trophoblast leucocyte common antigen, trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen

Rabbit

IgG

Membrane cofactor protein

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Human, Mouse

-20°C or -80°C

41116161