Western Blot Positive WB detected in: Hela whole cell lysate, Mouse liver tissue All lanes: CD46 antibody at 3microg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 44, 45, 43, 41, 42, 40, 37 kDa Observed band size: 44 kDa
Western Blot Positive WB detected in: Hela whole cell lysate, Mouse liver tissue All lanes: CD46 antibody at 3microg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 44, 45, 43, 41, 42, 40, 37 kDa Observed band size: 44 kDa
CD46 Antibody
CSB-PA004939EA01HU
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
TargetCD46
Overview
- SupplierCusabio
- Product NameCD46 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID4179
- Target nameCD46
- Target descriptionCD46 molecule
- Target synonymsAHUS2; antigen identified by monoclonal antibody TRA-2-10; CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein; complement membrane cofactor protein; MCP; measles virus receptor; membrane cofactor protein; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MIC10; TLX; TRA2.10; trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen
- HostRabbit
- IsotypeIgG
- Protein IDP15529
- Protein NameMembrane cofactor protein
- Scientific DescriptionActs as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
- Storage Instruction-20°C or -80°C
- UNSPSC12352203
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